12 D2 12 39.7 cM Start 85,473,890 End 85,477,273 pattern Molecular function. Cellular component. Biological process. Sources: / Species Human Mouse RefSeq (mRNA) RefSeq (protein) Location (UCSC) search In the fields of and, c-Fos is a that is the human homolog of the retroviral v-fos. It was first discovered in rat as the transforming gene of the FBJ MSV (Finkel–Biskis–Jinkins murine osteogenic sarcoma virus) (Curran and Tech, 1982). It is a part of a bigger Fos family of which includes c-Fos,. It has been mapped to chromosome region 14q21→q31.
This entry has information about the startup entry named cfosspeed that points to the cFosSpeed.exe file. It is up to you if this program should automatically start. An explanation of how cfosspeed.exe (cFosSpeed Window) is used and what problems it can cause.
C-Fos encodes a 62 kDa protein, which forms heterodimer with (part of Jun family of transcription factors), resulting in the formation of (Activator Protein-1) complex which binds DNA at AP-1 specific sites at the promoter and enhancer regions of target genes and converts extracellular signals into changes of gene expression. It plays an important role in many cellular functions and has been found to be overexpressed in a variety of cancers. Contents. Structure and function c-fos is a 380 amino acid protein with a basic region for dimerisation and DNA-binding and a transactivation domain at C-terminus, and, like Jun proteins, it can form homodimers. In vitro studies have shown that Jun–Fos heterodimers are more stable and have stronger DNA-binding activity than Jun–Jun homodimers. A variety of stimuli, including, tumor promoters, and UV radiation induce their expression.
The c-fos mRNA and protein is generally among the first to be expressed and hence referred to as an. It is rapidly and transiently induced, within 15 minutes of stimulation. Its activity is also regulated by posttranslational modification caused by phosphorylation by different kinases, like, cdc2, PKA or PKC which influence protein stability, DNA-binding activity and the trans-activating potential of the transcription factors.
It can cause gene repression as well as gene activation, although different domains are believed to be involved in both processes. It is involved in important cellular events, including cell proliferation, differentiation and survival; genes associated with; and; which makes its dysregulation an important factor for cancer development.
It can also induce a loss of cell polarity and, leading to invasive and metastatic growth in mammary epithelial cells. The importance of c-fos in biological context has been determined by eliminating endogenous function by using anti-sense mRNA, anti-c-fos antibodies, a that cleaves c-fos mRNA or a dominant negative mutant of c-fos. The transgenic mice thus generated are viable, demonstrating that there are c-fos dependent and independent pathways of cell proliferation, but display a range of tissue-specific developmental defects, including, delayed, lymphopenia and behavioral abnormalities. Clinical significance.
This diagram depicts the signaling events in the that are induced by chronic high-dose exposure to psychostimulants that increase the concentration of synaptic dopamine, like,. Following presynaptic and by such psychostimulants, for these trigger internal signaling events through a and a that ultimately result in increased CREB phosphorylation.
Phosphorylated CREB increases levels of ΔFosB, which in turn represses the c-Fos gene with the help of; c-Fos acts as a molecular switch that enables the accumulation of ΔFosB in the neuron. A highly stable (phosphorylated) form of ΔFosB, one that persists in neurons for 1–2 months, slowly accumulates following repeated high-dose exposure to stimulants through this process. ΔFosB functions as 'one of the master control proteins' that produces addiction-related, and upon sufficient accumulation, with the help of its downstream targets (e.g., ), it induces an addictive state.
The AP-1 complex has been implicated in and progression of. In and endometrial carcinoma, c-Fos overexpression was associated with high-grade lesions and poor prognosis. Also, in a comparison between precancerous lesion of the cervix uteri and invasive cervical cancer, c-Fos expression was significantly lower in precancerous lesions. C-Fos has also been identified as independent predictor of decreased survival in.
It was found that overexpression of c-fos from class I MHC promoter in transgenic mice leads to the formation of osteosarcomas due to increased proliferation of osteoblasts whereas ectopic expression of the other Jun and Fos proteins does not induce any malignant tumors. Activation of the c-Fos transgene in mice results in overexpression of cyclin D1, A and E in osteoblasts and chondrocytes, both in vitro and in vivo, which might contribute to the uncontrolled growth leading to tumor. Human osteosarcomas analyzed for c-fos expression have given positive results in more than half the cases and c-fos expression has been associated with higher frequency of relapse and poor response to chemotherapy. Several studies have raised the idea that c-Fos may also have tumor-suppressor activity, that it might be able to promote as well as suppress tumorigenesis. Supporting this is the observation that in ovarian carcinomas, loss of c-Fos expression correlates with disease progression.
This double action could be enabled by differential protein composition of tumour cells and their environment, for example, dimerisation partners, co-activators and promoter architecture. It is possible that the tumor suppressing activity is due to a proapoptotic function. The exact mechanism by which c-Fos contributes to is not clearly understood, but observations in human hepatocellular carcinoma cells indicate that c-Fos is a mediator of c-myc-induced cell death and might induce apoptosis through the p38 MAP kinase pathway. Fas ligand (FASLG or FasL) and the tumour necrosis factor-related apoptosis-inducing ligand (TNFSF10 or TRAIL) might reflect an additional apoptotic mechanism induced by c-Fos, as observed in a human T-cell leukaemia cell line. Another possible mechanism of c-Fos involvement in tumour suppression could be the direct regulation of BRCA1, a well established factor in familial breast and ovarian cancer. In addition, the role of c-fos and other Fos family proteins has also been studied in endometrial carcinoma, cervical cancer, mesotheliomas, colorectal cancer, lung cancer, melanomas, thyroid carcinomas, esophageal cancer, hepatocellular carcinomas, etc. Cocaine, methamphetamine, heroin, and other psychoactive drugs have been shown to increase c-fos production in the (prefrontal cortex) as well as in the (nucleus accumbens).
C-Fos repression by 's within the of the acts as a molecular switch that enables the chronic induction of ΔFosB, thus allowing it to accumulate more rapidly. As such, the c-Fos promoter finds utilization in drug addiction research in general, as well as with context-induced relapse to drug-seeking and other behavioral changes associated with chronic drug taking.
An increase in c-Fos production in androgen receptor-containing neurons has been observed in rats after mating. Applications Expression of c-fos is an indirect marker of neuronal activity because c-fos is often expressed when neurons fire action potentials. Upregulation of c-fos mRNA in a neuron indicates recent activity.
The c-fos promoter has also been utilised for drug abuse research. Scientists use this promoter to turn on transgenes in rats, allowing them to manipulate specific neuronal ensembles to assess their role in drug-related memories and behavior.
This neuronal control can be replicated with or Interactions c-Fos has been shown to with:.,.,.,.,.,.,.,.,.,.,., and. See also. References. Murphy LC, Alkhalaf M, Dotzlaw H, Coutts A, Haddad-Alkhalaf B (June 1994).
'Regulation of gene expression in T-47D human breast cancer cells by progestins and antiprogestins'. 9 Suppl 1: 174–80. Pompeiano M, Cirelli C, Arrighi P, Tononi G (1995). 'c-Fos expression during wakefulness and sleep'.
Neurophysiol Clin. 25 (6): 329–41. Herrera DG, Robertson HA (October 1996). 'Activation of c-fos in the brain'. 50 (2–3): 83–107. Velazquez Torres A, Gariglio Vidal P (2002).
'Possible role of transcription factor AP1 in the tissue-specific regulation of human papillomavirus'. (in Spanish). 54 (3): 231–42. External links. at the US National Library of Medicine (MeSH). at the US National Library of Medicine (MeSH).
Human genome location and gene details page in the.
What is cFosSpeed? CFosSpeed is a network driver, which attaches itself to existing Internet connections. It then optimizes data transfer by means of Traffic Shaping. Traffic Shaping is a method for optimizing the Internet traffic. It allows maximum speed while ensuring minimal Ping.
You can use cFosSpeed with a router and/or a DSL-modem or cable-modem. You can also use cFosSpeed with other types of Internet access, i.e. Whenever you already have an existing Internet connection. CFosSpeed supports a wide variety of connections, like DSL, cable, ISDN, UMTS, WiMAX etc. CFosSpeed has two goals.
Keep network delays (ping times) small, in order to make Internet applications as responsive as possible. Improve data throughput by avoiding network congestions.
You can use cFosSpeed with an Internet connection you use exclusively or which you share with several PCs.